Penne alla vodka is a popular meal consisting of penne pasta, heavy cream, tomato sauce, and vodka, imparting a unique taste to the whole dish. Its origins are quite murky, so some food historians claim it was invented in Bologna, Italy, while others say that it was invented in New York.

Regardless of the origins, it remains a popular pasta dish that is served hot, often garnished with a few basil leaves and grated parmesan.

Crawfish Monica is an American dish consisting of rotini pasta, crawfish tails, garlic, Creole seasoning, butter, and cream. The dish was invented in Louisiana by Pierre Hilzim, who named it after his wife, Monica Davidson. The recipe is kept a secret, and the name of the dish is trademarked.

In the 1980s, Davidson and Hilzim started to sell their dish at Jazzfest, and it didn't take a long time for crawfish Monica to become one of the most popular dishes at the festival.

Mac and cheese—a seemingly simple combination of macaroni and melted cheese—is one of the most popular dishes in the United States. The preferred American combination consists of curved macaroni pasta and Cheddar cheese, but modern varieties include vegetables, breadcrumb toppings, or gourmet ingredients such as crab, lobster, or truffles.

Although it is an American staple, the dish was probably inspired by similar pasta dishes enjoyed in Italy and France. In the United States, it was popularized by none other than Thomas Jefferson. He fell in love with the combination of pasta and cheese during his European travels, and soon after returning, he started importing macaroni and had the pasta machine shipped to Virginia. 

Baked ziti is a casserole-type dish consisting of tubular pasta called ziti that is baked with a variety of other ingredients, mostly chunky sauces, cheese, meat, and vegetables such as mushrooms, peppers, and onions. The dish is considered a hybrid of Italian and American cuisines, basically an Americanized variety of a typical Italian dish, pasta al forno, which is commonly compared to baked ziti.

The casserole is often served as a casual appetizer, cut into big slices, and it is best accompanied by a bowl of green salad. However, it can also be served as a meal on its own, making it a great comfort food for a rainy afternoon. Interestingly, the dish was especially popularized when it appeared in an episode of the hit TV show The Sopranos as one of the favorite dishes of Tony Soprano's wife, Carmela.

Contrary to popular belief, spaghetti and meatballs is not an Italian dish, and if one travels to Italy, it will appear on some menus simply to satisfy the appetites of some American tourists. Consisting of spaghetti combined with tomato sauce and ground beef meatballs, the dish was originally invented by Italian immigrants who came to America in the 19th century.

Since canned tomatoes were among the only items available in stores, home cooks used to prepare a rich marinara sauce with garlic, oil, and tomatoes. Spaghetti were also one of the only Italian ingredients available in stores, so the thin, long pasta also became more popular in the homes of newly arrived immigrants. 

The dish that's known in the United States as fettuccine Alfredo is just an extra-buttery version of pasta al burro, an Italian classic made with fettuccine, butter, and Parmigiano-Reggiano cheese. The story of fettuccine Alfredo dates back to 1908 in Rome.

Chef Alfredo Di Lelio first created this dish for his pregnant wife out of a desire to create something simple, yet tasty and nutritious, and he subsequently began serving it at his restaurant. He added more butter and cheese to the original recipe for pasta al doppio burro, and created a hearty triple butter sauce in the process. 

Toasted ravioli is a St. Louis specialty consisting of crunchy, breaded pasta that is topped with grated parmesan and served with a marinara-style sauce on the side. The dish is served hot as an appetizer. Despite the name, toasted ravioli are deep-fried, not toasted, making it yet another example of a misnomer.

Food experts believe that the first iteration of the dish was made in the 1950s, at a restaurant called Angelo Oldani's. The ravioli can be filled with a variety of ingredients, and some of the most popular ingredients include eggs, cheese, spinach, and beef.

Pasta primavera is a dish combining pasta and lightly cooked vegetables along with some fresh herbs and spices. Despite its Italian-sounding name, the dish was actually invented by Ed Giobbi during his hunting trip to Nova Scotia. He brought the recipe to New York City and gave it to his friends Jean Vernges and Sirio Maccioni, who used it in their new restaurant named Le Cirque.

The original pasta primavera incorporated ingredients such as ripe tomatoes, chopped basil, parsley, and garlic, olive oil, and spaghetti. In 1976, it was the most talked-about dish in Manhattan, and it is still popular today.

American chop suey is a savory combination of baked pasta, ground beef, and tomato sauce. It's believed that this comfort food dish originates from New England, although many other states had similar recipes before the 1950s. It can be prepared stovetop in a pot or baked as a casserole.

Most people like to add grated cheese to the combination, making the dish perfect for cold winter days. Variations abound throughout the country, but elbow macaroni or other tubular pasta shapes are the most common, while ingredients such as Worcestershire sauce, onions, and garlic are included in most recipes.