Biscotti regina or the queen's cookies are crunchy, sesame seed coated biscuits that originated in Palermo, but nowadays can be found all over Sicily. Allegedly named after Queen Margherita of Savoia, these tasty treats are both sweet and savory in flavor due to the lightly toasted sesame crust which envelops the tender interior.

Traditionally, reginelle are enjoyed dipped in sweet dessert wines such as Marsala or Vin Santo, but they are also wonderful when dunked in coffee, hot chocolate, or tea.