Châteauneuf-du-Pape is the largest and the most important appellation in the southern part of the Rhône Valley that comprises of five communes. Most Châteauneuf-du-Pape wines are predominantly red blends, with a small percentage of whites.

This powerful red wine hails from the southern Rhône, and it is mostly based on Grenache with small proportions of Syrah and Mourvedre. Often compared to the more famous Châteauneuf-du-Pape, these robust wines are characterized by their deep ruby color and complex aromas of ripe red and black fruit that are complemented by spicy and earthy nuances of licorice, cocoa, or chocolate. Gigondas is a full-bodied wine with powerful tannins that tend to mellow with age, resulting in more refined expressions.

Red wines from the Ventoux appellation are primarily based on Grenache, Carignan, Cinsault, Syrah, and Mourvèdre grapes. These ruby red, fruit-forward wines typically display aromas of ripe red fruit that are occasionally complemented by subtle notes of spices, licorice, or oak.

Vacqueyras is a French appellation located in the Rhône. Although white and some amount of rosé wines are produced in Vacqueyras, dry red wines are the hallmark of the region. These garnet-colored and rich wines are based on Grenache, but Syrah and Mourvèdre must make up at least 20 percent of the blend.

Rasteau is a French wine region that has a status of Côtes du Rhône Villages Cru. It is used for powerful dry red wines made from Grenache, usually with the addition of Mourvèdre and Syrah. Rasteau is also known for naturally sweet wines (vins doux naturel), made by adding pure grape spirit to fermented grape juice.

Muscat de Beaumes de Venise is a French appellation for dessert wines. The region is located in Southern Rhône, between Châteauneuf, Gigondas, and Vacqueyras. Initially, the appellation only included white wines, but red and rosé styles are now also permitted.