Muscadet Sèvre et Maine is the best-known region of the Muscadet appellation. The region is also one of the largest in terms of production and size. It spreads across twenty communes in the Loire-Atlantique department. The name is a reference to the two rivers that flow through the area, Sèvre Nantaise and Maine.
All the wines are produced from Melon de Bourgogne variety. The entire region is focused on the production of dry white wines and sur lie (aged on lees) styles. The wines are quite versatile and terroir-driven. They include floral, fruity, and mineral examples.